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January 2017
Volume 4 | Issue 1

Save the Date - March 30, 2017 PaLM Research Day



Dr. Martin Chalfie is one of the world’s most celebrated scientists and received the Nobel Prize for Chemistry in 2008 together with Osamu Shimomura and Roger Y. Tsien "for the discovery and development of the green fluorescent protein, GFP".  The discovery has completely changed the landscape of biomedical research and represents the most common way of labelling proteins in cells and animals.  Dr. Chalfie has continued to provide biological insights into nerve cell development and function, and the mechanisms of neurodegeneration.  His seminal contributions have been recognized with other prestigious awards as well, including the Distinguished Scientist Award by the American Heart Association, the Golden Goose Award, and the Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Science.  We are truly honoured that Dr. Chalfie will deliver the Paterson Lecture.

WE SPEAK: Faculty & Staff Survey 2017

Your feedback is valuable and important, as it will offer insights that can start conversation for positive change within your Faculty/Division and at Western as a whole. The survey will take approximately 20 minutes. Check your email for your unique survey link.  Read more

PaLM Twitter Account

We are very excited to let you know that the department now has a Twitter account. If you are a Twitter user, please, please, follow us. You can find us on Twitter by searching for @westernuPaLM.  Read more

Congratulations to Dr. Mark Darling

Dr. Mark Darling made the USC Teaching Honour Roll 2015-2016 in Dentistry.  Read more

News Stories

Update In PathologyPathology Matters

Dr. Matt Cecchini was one of many pathologists and researchers, including 21 trainees, to attend the inaugural Pathology Matters meeting hosted by the Ontario Molecular Pathology Research Network (OMPRN).  Read more
Update In PathologyJAF Stevenson Memorial Scholarship recipient

Rebecca Mantha, a PaLM alumna (MClSc - 2014), was the recipient of a JAF Stevenson Memorial Scholarship.  Read more
Update In PathologyCongratulations to the following Graduate Students

Hayley Good, MSc Candidate with Dr. Samuel Asfaha on receiving an LHRI studentship for 2017.  Rebecca Sullivan, MSc Candidate with Dr. Savita Dhanvantari on receiving an LHRI Studentship for 2017.  Kara Ruicci, MD/PhD Candidate with Dr. Anthony Nichols on receiving the Otolaryngology Graduate Research Stipend for 2017.
Update In PathologyCongratulations Dr. Cady Pocrnich

Dr. Cady Pocrnich received her official Diploma for AFC in Cytopathology in December 2016! Congratulations to Cady for all her hard work and to the team for supporting her. 
Update In PathologyA small but powerful team

The Master of Clinical Pathologists’ Assistant Program at Schulich Medicine & Dentistry may be small in size, but that doesn’t take anything away from the impact of their work and commitment to the community. We sat down with one of just six students in the program, Stephanie Sharpley, to understand how the department separates itself from others and provides students a highly specialized experience.  Click here
Update In PathologyWPA Lecture Series: Ms. Katie Logan

The WPA welcomed back Ms. Katie Logan, MCISc 2012, Pathologists’ Assistant program on January 20, 2017. Katie gave a talk titled “The Road to Becoming a Pathologists' Assistant: the Good, the Bad and the Ugly”. It was well attended by undergraduate students interested in the PA program, current graduate students, faculty and staff.  Click here
Update In PathologyWPA Undergraduate Journal Critique Workshop

WPA hosted the third annual Journal Critique Workshop on January 17th, 2017. Milica Krstic, on behalf of the WPA executive council, provided tips and guidance for the fourth-year undergraduate Pathology students to read more critically and prepare for the Journal Critique presentations.  Click here

Upcoming Events

Pathology and Laboratory Medicine Zhong Seminar - February

"Non-communicable diseases (NCDs), a legacy of an adverse in utero environment?"

Speaker: Dr. Tim Regnault
Thursday, February 23, 2016 @ 12:00 pm - LHSC UH Auditorium B | Click here

Publications

  1. McGee J, Panabaker K, Leonard S, Ainsworth P, Elit L, Shariff SZ. Genetics Consultation Rates Following a Diagnosis of High-Grade Serous Ovarian Carcinoma in the Canadian Province of Ontario. Int J Gynecol Cancer, 2017 Jan 9.  DOI: 10.1097/IGC.0000000000000907. PMID 28072594.
     
  2. Hood RL, Schenkel LC, Nikkel SM, Ainsworth PJ, Pare G, Boycott KM, Bulman DE, Sadikovic B. The defining DNA methylation signature of Floating-Harbor Syndrome. Sci Rep, 2016 Dec 9; 6: 38803.  DOI: 10.1038/srep38803. PMID 27934915.
     
  3. Iqbal J, Nussenzweig A, Lubinski J, Byrski T, Eisen A, Bordeleau L, Tung NM, Manoukian S, Phelan CM, Sun P, Narod SA, Hereditary Breast Cancer Research Group (incl. Ainsworth P). The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study. Br J Cancer, 2016 May 10; 114 (10): 1160-4.  DOI: 10.1038/bjc.2016.58. PMID 26986251.
     
  4. Gronwald J, Glass K, Rosen B, Karlan B, Tung N, Neuhausen SL, Moller P, Ainsworth P, Sun P, Narod SA, Lubinski J, Kotsopoulos J, Hereditary Breast Cancer Clinical Study Group. Treatment of infertility does not increase the risk of ovarian cancer among women with a BRCA1 or BRCA2 mutation. Fertil Steril. 2016 Mar 1, 105. (3): p.781-5.  DOI: 10.1016/j.fertnstert.2015.11.034. PMID 26698676
     
  5. Ethier C, Yu Y, Cameron L, Lacy P, Davoine F.  Calcitriol Reduces Eosinophil Necrosis Which Leads to the Diminished Release of Cytotoxic Granules.  Int Arch Allergy Immunol. 2016;171(2):119-129. DOI: 10.1159/000450951. Epub 2016 Dec 1.  PMID:  27902981
     
  6. Hsia CC, Mahon JL, Seitelbach M, Chia J, Zou G, Chin-Yee IH. Use of n-of-1 (single patient) trials to assess the effect of age of transfused blood on health-related quality of life in transfusion-dependent patients. Transfusion, 2016 May 1; 56 (5): 1192-200.  DOI: 10.1111/trf.13484. PMID 26840915
     
  7. Louzada ML, Hsia CC, Al-Ani F, Ralley F, Xenocostas A, Martin J, Connelly SE, Chin-Yee IH, Minuk L, Lazo-Langner A. Randomized double-blind safety comparison of intravenous iron dextran versus iron sucrose in an adult non-hemodialysis outpatient population: A feasibility study. BMC Hematol, 2016 Jan 1; 16: 7.  DOI: 10.1186/s12878-016-0046-8. PMID 26973791
     
  8. da Silveira Cavalcante L, Feng Q, Chin-Yee I, Acker JP, Holovati JL. Effect of liposome-treated red blood cells in an anemic rat model. J Liposome Res, 2016 Apr 8: 1-8.  DOI: 10.3109/08982104.2016.1149867. PMID 27055898
     
  9. Gottheil S, Khemani E, Copley K, Keeney M, Kinney J, Chin-Yee I, Gob A. Reducing inappropriate ESR testing with computerized clinical decision support. BMJ Qual Improv Rep, 2016 Jan 1; 5 (1).  DOI: 10.1136/bmjquality.u211376.w4582. PMID 27096092
     
  10. Darling MR, Woodford R, Cuddy KK, Jackson-Boeters L, Hayter A, Inkaran J, Diamandis EP, Khan Z. Kallikrein-related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study. J Investig Clin Dent. 2017 Jan 4. DOI: 10.1111/jicd.12256. [Epub ahead of print] PMID: 28054463.
     
  11. Delport JA, Strikwerda A, Armstrong A, Schaus D, John M. MALDI-ToF short incubation identification from blood cultures is associated with reduced length of hospitalization and a decrease in bacteremia associated mortality. Eur J Clin Microbiol Infect Dis  pp 1-6  DOI:   10.1007/s10096-017-2906-y. Published online 20-Jan-2017.
     
  12. Leach MD, Kim T, DiGregorio SE, Collins C, Zhang Z, Duennwald ML, Cowen LE. Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity. G3 (Bethesda), 2017 Jan 5; 7 (1): 95-108, DOI: 10.1534/g3.116.035675. PMID 27807047
     
  13. Gibson CJ, Abrams KJ, Pletcher T. (2016)   Health Information Exchange as a Profession. In: HEALTH INFORMATION EXCHANGE: Navigating and Managing a Network of Health Information Systems.  Academic Press / Elsevier.  p.21-38.  DOI: 10.1016/B978-0-12-803135-3.00002-5
     
  14. Lobb I, Jiang J, Lian D, Liu W, Haig A, Saha MN, Torregrossa R, Wood ME, Whiteman M, Sener A. Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia-Reperfusion Injury via Specific Mitochondrial Actions. Am J Transplant. 2016 Oct 15. DOI: 10.1111/ajt.14080. [Epub ahead of print] PMID: 27743487.
     
  15. Spence JD, Hammond R. (2016)  Hypertension and Stroke. In: Hypertension and the Brain as an End-Organ Target. Springer International Publishing  p.39-54 DOI: 10.1007/978-3-319-25616-0_3.
     
  16. Cocker MS, Spence JD, Hammond R, Wells G, deKemp RA, Lum C, Adeeko A, Yaffe MJ, Leung E, Hill A, Nagpal S, Stotts G, Alturkustani M, Hammond L, DaSilva J, Hadizad T, Tardif JC, Beanlands RS, Canadian Atherosclerosis Imaging Network (CAIN). [18F]-NaF PET/CT Identifies Active Calcification in Carotid Plaque. JACC Cardiovasc Imaging. 2016 Jun 10, Letter to the Editor. DOI: 10.1016/j.jcmg.2016.03.005 PMID 27318719.
     
  17. Lemieux C, Gardam M, Evans G, John M, Suh KN, vanWalraven C, Vicencio E, Coulby C, Roth V, Hota S.  Longitudinal Multicenter Analysis of Outcomes After Cessation of Control Measures for Vancomycin-Resistant Enterococci.  Infect Control Hosp Epidemiol. 2017 Jan;38(1):24-30. DOI: 10.1017/ice.2016.235  PMID:  27804901.
     
  18. Taylor G, Gravel D, Matlow A, Embree J, LeSaux N, Johnston L, Suh KN, John M, Embil J, Henderson E, Roth V, Wong A; Canadian Nosocomial Infection Surveillance Program.  Assessing the magnitude and trends in hospital acquired infections in Canadian hospitals through sequential point prevalence surveys.  Antimicrob Resist Infect Control. 2016 May 21;5:19.  DOI: 10.1186/s13756-016-0118-3. eCollection 2016.  PMID:  27213039
     
  19. Pacheco I, Buzea C.   (2016)  Nanoparticle interaction with plants.  Invited book chapter in Nanoscience and Plant-Soil Systems.  Springer Soil Biology Series, 978-3-319-46835-8, Hardcover ISBN 978-3-319-46833-4.   http://www.springer.com/us/book/9783319468334.
     
  20. Buzea C, Pacheco I.  (2016)  Nanomaterials and nanoparticles: origin and activity. In:  Nanoscience and Plant-Soil Systems.  Springer Soil Biology Series, 978-3-319-46835-8, Hardcover ISBN 978-3-319-46833-4.   http://www.springer.com/us/book/9783319468334.​
     
  21. Pacheco I, Buzea C.   (2017)  Nanomaterials toxicity.   In:  Advanced Environmental Analysis: Applications of Nanomaterials. Vol. 2.  The Royal Society of Chemistry, ISBN: 978-1-78262-907-8.   http://pubs.rsc.org/en/content/ebook/978-1-78262-907-8#!divbookcontent.
     
  22. Buzea C, Pacheco I.  (2017)  Nanomaterials and their classification.   In:  EMR/ESR/EPR spectroscopy for characterization of nanomaterials.  Springer Book Series: Advance Structured Materials, ISBN 978-81-322-3653-5 ISBN 978-81-322-3655-9.   http://www.springer.com/la/book/9788132236535.
     
  23. Pacheco I, Buzea C.   (2017)  Metal nanoparticles and their toxicity.  In:  Metal Nanoparticles. Synthesis and Applications in Pharmaceutical Sciences.  Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, ISBN: 978-3-527-33979-2.  http://ca.wiley.com/WileyCDA/WileyTitle/productCd-3527339795.html.
     
  24. Poon AFY. Impacts and shortcomings of genetic clustering methods for infectious disease outbreaks. Virus Evolution. Volume 2, Issue 2, July 2016 DOI: 10.1093/ve/vew031
     
  25. Sweeney NP, Regan C, Liu J, Galleu A, Dazzi F, Lindemann D, Rupar CA, McClure MO.  Rapid and Efficient Stable Gene Transfer to Mesenchymal Stromal Cells Using a Modified Foamy Virus Vector.  Mol Ther. 2016 Aug 1; 24 (7): 1227-36.  DOI: 10.1038/mt.2016.91  PMID 27133965.
     
  26. Kelland E, Rupar CA, Prasad AN, Tay KY, Downie A, Prasad C. Response to: Letter to the Editor Regarding: The Expanding Phenotype of MELAS Caused by the m.3291 T > C tRNA Mutation E Kelland, C. A. Rupar, Asuri N. Prasad, K. Y. Tay, A. Downie and C. Prasad (1) by Josef Finsterer, MD, PhD [1], Sinda Zarrouk-Mahjoub, PhD [2] [1] Krankenanstalt Rudolfstiftung, Vienna [2] Genomics Platform, Pasteur Institute of Tunis, Tunisia. Mol Genet Metab Rep, 2016 Jul 15; 8: 41-2.  DOI: 10.1016/j.ymgmr.2016.07.002  PMID 27493879.
     
  27. Oud MM, Bonnard C, Mans DA, Altunoglu U, Tohari S, Ng AY, Eskin A, Lee H, Rupar CA, de Wagenaar NP, Wu KM, Lahiry P, Pazour GJ, Nelson SF, Hegele RA, Roepman R, Kayserili H, Venkatesh B, Siu VM, Reversade B, Arts HH.  A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.  Cilia, 2016 Apr 11; 5: 8.  DOI: 10.1186/s13630-016-0029-1  PMID 27069622.
     
  28. Keilland E, Rupar CA, Prasad AN, Tay KY, Downie A, Prasad C.  The expanding phenotype of MELAS caused by the m.3291T > C mutation in the MT-TL1 gene.  Mol Genet Metab Rep, 2016 Feb 22; 6: 64-9.  DOI: 10.1016/j.ymgmr.2016.02.003  PMID 27014580.
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