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March 2017
Volume 4 | Issue 3

Pathology and Laboratory Medicine Research Day - March 30, 2017



We held yet another amazing Research Day on March 30th at the Great Hall, Somerville House. Unlike previous years, the Paterson Lecture did not coincide with the Research Day in 2017. However, it did not take anything away from one of the most successful showcases of our research achievements in the Department’s history. The day began with opening remarks from Dr. Subrata Chakrabarti, Chair/Chief of Pathology and Laboratory Medicine. In his remarks, Dr. Chakrabarti reinforced and reaffirmed the Department’s vision and mission. He also provided a snapshot of our accomplishments over the past few years and highlighted a few novel future developments. Following the opening remarks, participants were treated to a lineup of a record-breaking 71 abstract presentations. Almost half of all faculty in our Department served as judges and interacted with our young, talented researchers throughout the day.  There was certainly a buzz and an excitement in the air.  It was great to see the breadth of our research activities. 

The day concluded with a celebration of the hard work all presenters put into presenting their research. A number of awards denoting exceptional performance in platform and poster presentation were presented at the Awards Ceremony at Windermere Manor.
 
The day was successful because of the effort of the presenters, the 24 judges who devoted their valuable time to interact with the presenters, and the Pathology and Laboratory Medicine Research Day Committee. Special thanks to Kathilyn Allewell, Tracey Koning, Cheryl Campbell, Mellonie Carnahan, Linda Jackson-Boeters, Nancy Chan, Martin Duennwald, Manal Gabril, Zia Khan, Emily Goebel, Jina Kum, Vy Ngo, Terry Robins, Shannon Hubbert, Susan Underhill, and Mair Hughes.

We would like to express a heartfelt thank you to all the judges:
 
Guest Judges:
Brian Chow (Toronto), Deborah Lenz (London), Dr. Iram Siddiqui (Toronto), Dr. Rebekah Jacques (Toronto).
 
Pathology and Laboratory Medicine Judges:
Drs. Alan Tuck, Art Poon, Bekim Sadikovic, Chandan Chakraborty, Christopher Howlett, Edith Arany, Hon Leong, Joan Knoll, Johan Delport, Lisa Cameron, Manal Gabril, Mark Darling, Martin Duennwald, Nancy Chan, Nikhil Sangle, Rob Hammond, Savita Dhanvantari, Stephanie Frisbee, Sunil Parapuram, and Zia Khan.

Top Row: Dr. Paul Plantinga, Dr. Matthew Cecchini, Dr. Emily Goebel, Farzad Asadi, Hayley Good, Richard Filek Bottom Row: Brittany Pillon, Jina JY Kum, Maham Bushra, Terry Robins, Anu Thomas



Platform Presentation Awards

Chair's Award for the Best Clinical Science Presentation
This award recognizes a Pathology Resident’s excellence in research design and performance as well as the presentation of the research topic. 
 
2017 Awardee: Dr. Matthew Cecchini
Title of the presentation: The Utility of CDX2 Loss as a Prognostic Marker in Stage II Colon Cancer.
         
Dr. M. Daria Haust Award for the Best Basic Science Presentation
This award recognizes a graduate student’s excellence in research design and performance as well as the presentation of the research topic. This award is given in recognition of Dr. M. Daria Haust’s many achievements in the Department of Pathology at the University of Western Ontario and London Health Sciences Centre. 
 
2017 Awardee: Hayley Good
Title of the presentation: The effect of non-steroidal anti-inflammatory drugs on the initiation of Dclk1+ tuft cell-derived colitis-associated cancer.
 

Poster Presentation Awards

Best Clinical Science Poster Presentation Award
This award recognizes a Pathology Resident’s excellence in research design and performance as well as the presentation of the poster. 
 
2017 Awardee: Dr. Paul Plantinga
Title of the presentation: Histological Elucidation of Tumour Deposits in Colorectal Adenocarcinoma.
 
Best Basic Science Poster Presentation Award
This award recognizes a Graduate Student’s excellence in research design and performance as well as the presentation of the poster. 
 
2017 Awardee: Farzad Asadi
Title of the presentation: A novel theory on mechanisms of glucagon secretion from pancreatic alpha cells.
 
Best Basic/Clinical Science Collaborative Poster Presentation
This award recognizes excellence in research design and performance as well as the presentation of a research poster. This award is given to a Graduate Student or a Pathology Resident to recognize collaborative basic and clinical science research. 
 
2017 Awardee: Jina JY Kum
Title of the presentation: Transforming growth factor-β1 pathway regulates differentiation of bone marrow-derived progenitor cells
         
Best Undergraduate Basic Science Poster Presentation
This award recognizes excellence in research design and performance as well as presentation of a research poster by an undergraduate student in Pathology modules of the Bachelor of Medical Science program. 
 
2017 Awardee: Maham Bushra
Title of the presentation: The Effects of Repeated Exposure to Whole Body Vibration on Murine Intervertebral Disc and Knee Joint Health.
 

Other Awards presented at Research Day

MClSc Graduate Research Award (two awardees)
This award recognizes excellence in research design and performance as well as the presentation of a research poster by a graduate student in the Master of Clinical Science – Pathologist’s Assistant program.
 
2017 Awardee: Terry Robins
Title of the presentation: Suitability of RNA Isolated from Archived Formalin-Fixed, Paraffin-Embedded Oral Dysplastic Lesions for Diagnosis of an HPV Etiology.
 
2017 Awardee: Brittany Pillon
Title of the presentation: Youth suicide age and sex related trends in Ontario First Nations communities: A comparison
 
The Cameron Wallace Graduate Student Award in Pathology
The award recognizes a graduate student’s high achievement in research, course work, and social involvement. 
2017 Awardee: Richard Filek 

Dr. P.C. Raju & Jyoti Shah Resident Research Prize
To recognize the Pathology resident with the best original or research article published by the resident as first author.

2017 Awardee: Dr. Emily Goebel
Title of the publication: Goebel EA, McCluggage WG, Walsh JC, Mitotically Active Sclerosing Stromal Tumor of the Ovary: Report of a Case Series With Parallels to Mitotically Active Cellular Fibroma. International Journal of Gynecological Pathology 2016; 35:549–553.
 
Dr. P.C. Raju & Jyoti Shah Graduate Education Prize
To recognize the Pathology and Laboratory Medicine graduate student with the best first-authored original or research article published.

2017 Awardee: Anu Thomas
Title of the publication: Thomas AA, Feng B, Chakrabarti S. ANRIL: A Regulator of VEGF in Diabetic Retinopathy. Invest Ophthalmol Vis Sci.2017;58:470-480.

Embracing the 'gross' side of pathology

While some may shy away from working with cadavers and performing gross examinations on human tissues or organs, Terry Lee Robins, a Master of Clinical Sciences–Pathologists' Assistant candidate, relishes the opportunity.  Read more

Grant awarded to Dr. Duennwald

Dr. Martin Duennwald has received a Western Strategic Support for CIHR (Accelerator) Success grant for his project, Cellular responses to protein misfolding in aging cells.  Read more

Spring PaLM clothing now available!

The Department of Pathology and Laboratory Medicine is selling a new line of Spring PaLM clothing. All orders must be in by May 1, 2017.  Read more

News Stories

Update In PathologyHeart and Stroke Foundation Grant

Congratulations to Dr Tianqing Peng who has been awarded a Heart and Stroke Foundation of Canada grant. The three-year grant entitled Junctophilin-2 protects the heart against ischemia/reperfusion injury by preventing junctin degradation runs from July 2017 to June 2020.  Read more
Update In PathologyTrainee success at 2017 ImNO Symposium

Rebecca Sullivan, MSc candidate, was awarded Honourable Mention in the poster presentation category for her project: Expression of the Growth Hormone Secretagogue Receptor and Ghrelin in Human Heart Failure. Rebecca’s supervisor is Savita Dhanvantari, PhD.  Read more
Update In PathologyCanadian Association of Gastroenterology Award

Congratulations to Alice Shin who received the 2017 Canadian Association of Gastroenterology (CAG) PhD Award (term: 2 years).  Read more
Update In PathologyCongratulations to the London Health Research Day award winners!

Milica Krstic, PhD candidate, received first place in the morning session of the feature platform presentations in Salon D, Mechanisms of Disease. Milica’s supervisors are Ann Chambers, PhD, and Dr. Alan Tuck.  Read more
Update In PathologyThree Minute Thesis Pre-heat

On March 13, Schulich Medicine & Dentistry students engaged in a battle of wits at the Three Minute Thesis (3MT) pre-heat. Taking on the challenge of explaining their research in just three minutes, eight students prevailed. Our own Janice Gomes will be moving on to the next round of the 3MT competition.
Update In PathologyWPA Lecture Series: Katie Moisse

On March 17th, 2017, the WPA welcomed back Pathology alumna, Dr. Katie Moisse, PhD. Katie is currently working as a scientific news editor at Spectrum (New York). Her interactive Science Communications Workshop, titled "Where science meets story-telling".  Read more
Update In PathologyWPA Board Game Night

On March 9th, the WPA hosted their second annual board games night at the Cardboard Café. With attendance from a mix of undergraduate, research, and PA students, our fun-filled evening was a great success!.  Read more
Update In PathologyBaby McCord

On March 14, 2017 at 11:06 am Dr. Christina McCord, her husband James and big brother Owen welcomed baby Ryan into their family. Everyone is doing well.

Upcoming Events

NERDs April Open Forum

"Let's Learn Together – Cooperative Learning in Medicine"

Speaker: Dr. Melanie Katsivo and Pei Jun Zhao
Thursday, April 13, 2017 @ 12:00 pm - LHSC UH, A3-100 | Click here

Publications

  1. Schenkel LC, Rodenhiser D, Siu V, McCready E, Ainsworth P, Sadikovic B. Constitutional Epi/Genetic Conditions: Genetic, Epigenetic, and Environmental Factors.  J Pediatr Genet. 2017 Mar;6(1):30-41. [Epub 2016 Nov 8]  DOI: 10.1055/s-0036-1593849  PMID: 28180025.
     
  2. Thwaites M J, Cecchini MJ, Talluri S, Passos DT, Carnevale J, Dick FA. Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control. Cell Div. 2017; 12: 3. PMCID: PMC5348811 DOI: 10.1186/s13008-017-0029-6.
     
  3. Driman D, Shick B. Image editing for pathologists. Histopathology 2017, 70, 840–841. DOI: 10.1111/his.13146
     
  4. CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins. Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S. MBio. 2016 Sep 27;7(5). pii: e01367-16. doi: 10.1128/mBio.01367-16. PMID: 27677791
     
  5. Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity. Leach MD, Kim T, DiGregorio S, Collins C, Zhang Z, Duennwald ML, Cowen LE. G3 (Bethesda). 2016 Nov 2. pii: g3.116.035675. doi: 10.1534/g3.116.035675. [Epub ahead of print] PMID:27807047
     
  6. Polyglutamine toxicity in yeast uncovers phenotypic variations between different fluorescent protein fusions. Jiang Y, Di Gregorio SE, Duennwald ML, Lajoie P.Traffic. 2016 Oct 13. doi: 10.1111/tra.12453. [Epub ahead of print] PMID:27734565
     
  7. Nahlawi L, Goncalves C, Imani F, Gaed M, Gomez JA, Moussa M, Gibson E, Fenster A, Ward AD, Abolmaesumi P, Mousavi P, Shatkay H. Models of temporal enhanced ultrasound data for prostate cancer diagnosis: the impact of time-series order. Proc. SPIE 10135, Medical Imaging 2017: Image-Guided Procedures, Robotic Interventions, and Modeling, 101351D (March 3, 2017) DOI: 10.1117/12.2255798.
     
  8. Filter ER, Gabril MY, Gomez JA, Wang PZT, Chin JL, Isawa J, Moussa M. Incidental Prostate Adenocarcinoma in Cystoprostatectomy Specimens: Partial Versus Complete Prostate Sampling. International Journal of Surgical Pathology. Article first published online: March 22, 2017. DOI: 10.1177/1066896917696745.
     
  9. Mary Fonseka T, McKinley GP, Kennedy SH. Is tetraethyl lead poison affecting contemporary indigenous suicides in Ontario, Canada? Psychiatry Res. 2017 Jan 7;251:253-254. DOI: 10.1016/j.psychres.2017.01.003. [Epub ahead of print] PMID: 28219024
     
  10. Li R, Zhang Y, Zheng X, Peng S, Yuan K, Zhang X, Min W. Synergistic suppression of autoimmune arthritis through concurrent treatment with tolerogenic DC and MSC. Sci Rep. 2017 Feb 23;7:43188. DOI: 10.1038/srep43188. PMID: 28230210.
     
  11. Nothnagel M, Fan G, Guo F, He Y, Hou Y, Hu S, Huang J, Jiang X, Kim W, Kim K, Li C, Li H, Li L, Li S, Li Z, Liang W, Liu C, Lu D, Luo H, Nie S, Shi M, Sun H, Tang J, Wang L, Wang CC, Wang D, Wen SQ, Wu H, Wu W, Xing J, Yan J, Yan S, Yao H, Ye Y, Yun L, Zeng Z, Zha L, Zhang S, Zheng X, Willuweit S, Roewer L. Revisiting the male genetic landscape of China: a multi-center study of almost 38,000 Y-STR haplotypes. Hum Genet. 2017 Jan 30. DOI: 10.1007/s00439-017-1759-x. [Epub ahead of print] Review. PMID: 28138773
     
  12. Lu J, Zheng X, Li F, Yu Y, Chen Z, Liu Z, Wang Z, Xu H, Yang W. Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells.Oncotarget. 2017 Jan 17. DOI: 10.18632/oncotarget.14695. [Epub ahead of print] PMID: 28107184
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