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May 2015
Volume 2 | Issue 5

Grand Opening of the Transplant Immunology Laboratory at UH

On May 4, 2015 the Department of Pathology and Laboratory Medicine held an official opening ceremony of the new Transplant Immunology Laboratory at University Hospital.  Dr. QingYong Xu, the newly recruited director for the Transplant Immunology Laboratory, was introduced and he led the tour of the new facilities. 

The first transplant laboratory at University Hospital opened in the mid-1970s and was a very small facility, employing four technologists with approximately 10-15 people on the waiting list for a kidney transplant. Volumes have changed significantly in the past 40 years.  The Transplant Immunology Laboratory now has 9 full-time medical laboratory technicians and there are 80-90 patients on the waiting list for a kidney transplant.  Testing is also done for bone marrow, heart, liver, kidney and pancreas transplants. 



The Transplant Immunology Laboratory received international recognition for playing a key role in the testing and evaluation for Cyclosporine treatment.  This work improved the five-year graph survival rate from 50% to 90%. 

Wahab A. Khan completes his PhD Thesis

The Department of Pathology and Laboratory of Medicine would like to offer congratulations to Wahab Khan, who has completed his PhD in Pathology, under the supervision of Drs. Joan Knoll and Peter Rogan. Wahab's thesis is titled:  "Chromatin structure and differential accessibility of homologous human mitotic metaphase chromosomes”. Dr. Khan will be leaving Western this summer for the Icahn School of Medicine at Mount Sinai in Manhattan, NY.  He will begin an American Board of Medical Genetics and Genomics Postdoctoral Fellowship in Clinical Cytogenetics and Molecular Genetics.

Jina J.Y. Kum completes her MSc Thesis

The Department of Pathology and Laboratory of Medicine would like to offer congratulations to Jina Kum, who has completed her MSc in Pathology. Dr. Zia Khan is Jina's MSc supervisor. The title of Jina's thesis is  "ß-adrenergic receptor-dependent and -independent  effects of propranolol in infantile hemangioma". Her work has highlighted the molecular mechanisms by which propranolol mediates the therapeutic effect in hemangioma patients. Jina is planning to stay at Western University with a number of offers to advance her education.

Meghan A. Piccinin completes her MSc Thesis

The Department of Pathology and Laboratory of Medicine would like to offer congratulations to Meghan Piccinin, who has completed her MSc in Pathology. Dr. Zia Khan is Meghan's MSc supervisor. The title of Meghan's thesis is  "Diabetic Bone Marrow & Stem Cell Dysfunction”. Meghan's work has identified how diabetes changes tissue microenvironment and causes impairment of reparative stem cells. Meghan will be leaving Western University to further her education and pursue a fulfilling medical career at Michigan State University. 

News Stories

Advances in the Practice of Cytopathology

The Department of Pathology and Laboratory Medicine had a very successful CME day in Pathology on May 2, 2015. This meeting was organized by the Department of Pathology and Laboratory Medicine, London Health Sciences Centre and the Schulich School of Medicine, in partnership with Mount Sinai Hospital in Toronto. We had a total of 97 attendees, 28 MDs (pathologists and residents) and 69 cytotechnologists. Our guest speaker Dr. Jeffery Krane, Associate Professor of Pathology, Harvard Medical School, Boston, as part of the ‘Bedard Lectureship’, spoke on the challenges with indeterminate thyroid aspirates. Other presentations covered a wide variety of relevant and challenging topics, including; recent changes in cervical cancer screening in Canada, crisis in cytotechnology in Ontario, an update on cytology laboratory practices in Ontario, cytology quality improvement initiates and a cytology slide seminar on diagnostic challenges.

Thank you to all of our speakers and participants for your contribution!

Update In Pathology2015 Schulich Award of Excellence winner - Dr. Michele Weir

We are delighted to share the news that Dr. Michele Weir was awarded the 2015 Schulich Award of Excellence for Graduate/Postgraduate Education - Educator Award on May 20, 2015. The award is in recognition of the time and energy that Dr. Weir has devoted to postgraduate education at Schulich. 
Update In PathologyDr. Arany keynote speaker at a symposium in Argentina

Dr. Edith Arany was an invited keynote speaker at the VI Latin American Symposium on Maternal-Fetal Interaction and Placenta that took place from April 13-16, 2015 in Argentina. She gave her talk on intrauterine programming of beta cell defects.
Update In PathologyTornado warning procedures for Western and LHSC

The start of warmer weather is a great opportunity to review the Western and LHSC tornado warning procedure. To learn more about Western's procedure, click here. For LHSC you can sign up for Tornado alerts, click here.
Update In PathologyKevin Wen-Yang Lim given award

The 2014-2015 Professor Colin Anderson Award was awarded to Kevin Wen-Yang Lim on May 21, 2015. This award is given to the undergraduate student who achieves the highest mark in the course Pathology 3245B, "Diseases of Organ Systems”. The Anderson Award is given in memory of Dr. Colin Anderson, who was a member of our Pathology faculty from 1973 to 1996, during which time he organized and coordinated this course.

Publications

  1. Cybulski C, Lubinski J, Huzarski T, Lynch HT, Randall SA, Neuhausen SL, Senter L, Friedman S, Ainsworth P, Singer C, Foulkes WD, Narod SA, Sun P, Kotsopoulos J.  Prospective evaluation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.  Breast Cancer Res Treat. 2015 Jun;151(2):435-41. doi: 10.1007/s10549-015-3393-4. PMID:  25935583. Epub 2015 May 3.
     
  2. Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L.  Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury  Am J Pathol.  2015 May;185(5):1207-15  DOI:  10.1016/j.ajpath.2015.02.003  PMID:  25759266.
     
  3. Taylor G, Gravel D, Saxinger L, Bush K, Simmonds K, Matlow A, Embree J, Le Saux NL, Johnston L, Suh KN, Embil J, Henderson E, John M, Roth V, Wong A, Bryce E, Dow G, Gardam M, Hutchinson J, Kibsey P, Langley J, Loeb M, McGeer A, Michaud S, Miller M, Moore D, Mulvey M, Ofner M, Paton S, Stegenga J, Weiss K, Zoutman D.  Prevalence of antimicrobial use in a network of Canadian hospitals in 2002 and 2009.  Can J Infect Dis Med Microbiol March/April 2015, Volume 26 Issue 2: 85-89.
     
  4. Alahmadi M, Chin-Yee IH, Gupta K, Rizkalla K, Hsia CC.  Leishmaniasis involving the bone marrow of a patient with multiple myeloma  Ann Hematol. 2015 Apr 17 [epub ahead of print]  PMID: 25876738.
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