Editor: Sara Davies
March 31, 2017
WELCOME DR. HOPPER!

Join us in welcoming Samuel P. Hopper, M.D., to the UAB Department of Pediatrics!
Samuel Hopper, M.D., Assistant Professor in Pediatric Neurology, earned his medical degree from Tulane School of Medicine. He completed his pediatric residency at UAB. He joins us from Jackson, Mississippi, where he worked with Children’s Medical Group, Batson Children’s Hospital and University of Mississippi Medical Center, and Mississippi Baptist Medical Center. His clinical and research interest is headaches in children. He sees headache patients at Children's South. 
UAB SIMULATION CONSORTIUM GAINS ACCREDITATION 

In January 2017, representatives from the Pediatric Simulation Center at Children’s of Alabama and the Office of Interprofessional Simulation accepted the certificate designating the UAB Simulation Consortium as accredited in Research, Education/Teaching, and Systems Integration by the Society of Simulation in Healthcare. Members of the Children's of Alabama and UAB simulation community traveled to the International Meeting on Simulation in Healthcare to accept this designation (pictured right). For more information on UAB Simulation Consortium, visit http://www.uab.edu/simulation/uab-simulation-consortium.  
7TH AVENUE SOUTH CONSTRUCTION

Beginning Monday, April 3, UAB will be closing thru traffic on 7th Avenue South from 16th Street to 14th Street. See attached traffic plans.
 
This closure will not restrict 7th Avenue parking deck entrance or exit for employees, patients, or physicians; however, it will restrict access from the West on 7th Avenue South. All access will have to come from the East on 7th Avenue South or from the South off University Boulevard. 

Street parking will not be allowed in this area during the closure period. Closure is planned to last 8-10 weeks. 

Closure Information. | Temporary Traffic Control.

Bob Crumpton 
Divisional Director of Engineering
Children's of Alabama 
PRIMARY CARE CLINIC (PCC) EXTRA MILE AWARD

The winner of the Primary Care Clinic Extra Mile Award for this quarter is Christa Nevin, M.D. She provided excellent care for a PCC patient with a long history of mental health concerns. She then took the extra time to contact the patient’s mental health providers and arrange close follow-up for this patient. Congratulations Dr. Nevin!
CHILDREN'S OF ALABAMA INCOMING PATIENT REPORT 

The Incoming Patient Report (IPR) tab is now available in iConnect. IPRs are started by Patient Placement for both Emergency Department and inpatient referrals. Patients are added to the tab when the referring physician calls “One Stop” / Patient Placement (205.638.7200). The IPR allows recording of clinical information prior to the patient’s arrival (or registration) for improved patient hand-off. Attending physicians may contribute additional details to the IPR once the patient has been added. Anyone on the clinical team can input information into the IPR. When the patient arrives at Children's of Alabama, documentation in the IPR tab will appear in the Documents tab within iConnect. In addition, you can find the previously arrived patient information on the ‘View Previous Patients’ section of the IPR.

Children's of Alabama Nursing Informatics Team
(nurseinformatics@childrensal.org)  
PSEUDOMONAS – IS THIS THE SCARIEST BUG OUT THERE?

P. aeruginosa (PsA) has been a scary infection for practitioners for decades; and now with MDR (multi-drug resistant) PsA becoming more common in some parts of the US including the south, the concern for adequate PsA coverage goes beyond the treatment of just pediatric CF patients.  At Children's of Alabama, Ceftazidime and Piperacillin/Tazobactam are still great empiric choices for PsA coverage (88% sensitivity for sterile sites based on current antibiogram). The good news is that we only had 10 sterile site infections with PsA in 2016 (8 blood/line + 2 CSF). Double coverage is not necessary for PsA for susceptible organisms, and with empirical therapy because of our low rate of MDR PsA. When concerned about PsA choose: Ceftazidime, Zosyn, or Cefepime, and reserve the addition of Gentamicin/Tobramycin for true MDR infections. Your patient's kidneys will thank you. Remember to avoid Piperacillin/Tazobactam with CNS infections. 
 
April Yarbrough, PharmD, BCPS
Pediatric Infectious Disease/Antimicrobial Stewardship Pharmacist
Pharmacokinetics Specialist
Children's of Alabama
IN THE NEWS 
UAB NEONATOLOGY STUDY SHOWS PRETERM BABIES BORN AT 23 WEEKS' OR LONGER GESTATION BENEFIT FROM MOM'S RECEIVING STEROIDS PRIOR TO DELIVERY 

A new study from UAB suggests that women at risk of preterm delivery, from as early as 23 weeks of pregnancy, should receive corticosteroids due to strong associations with a lower rate of death and serious illness for their babies. The study, published in the British Medical Journal, says that very premature babies seem to benefit the most from the steroids, even those born at 23 weeks of gestation.

“Indeed, the benefits of antenatal corticosteroids were substantially larger for infants born at the lowest gestations, including less than 28-week infants, for which data from randomized controlled trials are most limited,” said Wally Carlo, M.D., senior investigator of the study and director of the UAB Division of Neonatology.  

Compared to babies born at term, premature babies carry a greater risk of death or serious complications after birth, with problems tending to be more severe the earlier a baby is born. Infants exposed to antenatal corticosteroids had lower mortality and lower rates of brain bleeding. 

Colm Travers, M.D., third-year fellow in the UAB Division of Neonatology and principal investigator of the study, and a team of researchers analyzed data for 117,941 infants born between 23 and 34 weeks of gestation from 2009 to 2013 at 300 neonatal intensive care units across the United States. Death or major illness was analyzed by gestational age and exposure to antenatal corticosteroids, adjusting for factors such as birth weight, sex, mode of delivery and multiple births. 

Read the story at UAB News
SAVE THESE DATES
MASA LECTURE | APRIL 14

The Medical Association of the State of Alabama (MASA) is hosting a special lecture on Cannabis and Pain: Lessons from Colorado, with Kenneth P. Finn, M.D. Non-MASA members are invited to attend. This is a free event for healthcare providers. If interested, please RSVP to Dr. Shannon Murphy (shanandsteve@mindspring.com). More information
 

What: MASA Annual Conference: Lecture on Marijuana

Where: Renaissance Montgomery Hotel & Spa at the Convention Center 

When: Friday, April 14 at 1 p.m.
PEDIATRIC GASTROENTEROLOGY SPECIAL LECTURE 

Neelesh Tipnis, M.D.
Paul H. Parker Associate Professor 
The University of Mississippi Medical Center,
Jackson, Mississippi

Dr. Tipnis will present, “GERD: What do we do now?” 
McWane Building, Conference Room 1 | April 7, 2017 at 1 p.m.

 
CHIF SCHEDULE - MARCH 2017

April 7 | Noon | Bradley Lecture Center 

Potential Mechanisms Linking the Human Intestinal Microbiota to Juvenile Spondyloarthritis
Matt Stoll, M.D.
Associate Professor, Division of Pediatric Rheumatology


Please note location of this lecture only: Bradley Lecture Center

April CHIF schedule.
Please Note: All other CHIF meetings will be held in Surgical Commons.

SPRING SCRAMBLE | APRIL 22

Children’s of Alabama and the University of Alabama at Birmingham’s (UAB) Pediatrics Residency Program will host the 11th annual Spring Scramble 5K on Saturday, April 22. The 5K begins at 5:30 p.m. at the Levite Jewish Community Center, followed by a Fun Run at 6:30 p.m.
 
The registration fee is $20 for UAB and Children’s employees; $25 for the general public and free for children under 12 with an adult entry. The registration fee covers a 5K T-shirt and goodie bag. To register, visit www.springscramble.org.
COMPUTATIONAL GENOMICS - AN ADVANCED LEVEL IMMERSION COURSE FOR INVESTIGATORS AT UAB 

May 15-18 | 8:30 a.m. - 12:30 p.m. | Finley Conference Center

This course will provide the end user with a better knowledge of how to analyze their Genomics data using various Linux (command line) based analytical tools. Hands-on activities include analyzing whole genome for causal variants, transcriptome for gene expression, and epigenetics for calling peaks in ChIP/ATAC-Seq. More information
2017 CHILDREN'S GOLF TOURNAMENT - APRIL 13

Thursday, April 13 | Bent Brook Golf Course

Join us for a new take on an old tradition. The Children's of Alabama Golf Tournament, formerly the Children's of Alabama Corporate Golf Invitational, will include one round of golf and many added amenities. After the round, guests are invited to the patio with a Full Moon BBQ catered lunch featuring Cahaba Brewing Company.
Registration. | More Information
PEDIATRIC GRAND ROUNDS - UP NEXT: 

Thursday, April 6 | Noon | Bradley Lecture Center

“Mitochondrial Diseases”
Bruce H. Cohen, MD, FAAN
Director, Neuro Developmental Science Center
Department of Neurology, Akron Children’s Hospital, Akron, OH

Click here to view the April Pediatrics Grand Rounds schedule.
FELLOWSHIP NEWS
DIXON FELLOWSHIP CALL FOR APPLICATIONS

The Department of Pediatrics is now seeking applications for the Dixon Fellowship Training Program for the 2017 academic year. The Dixon Foundation endows this Pediatric fellowship training program to prepare, train, and support fellows who have completed their first year of training and intend to pursue an academic career with a research emphasis in approved Pediatric subspecialties.  

Applications should be emailed to cmallette@peds.uab.edu or delivered to Clare Mallette in 5 Dearth Tower, Suite 5606, no later than April 21, 2017.  The 2017 Dixon Fellows will be announced by the end of May 2017.

Questions? Please contact Clare Mallette.
Deadline: April 21 | More Information
CHU EDUCATION SCHOLARSHIP CALL FOR APPLICATIONS
 

We are pleased to announce a call for applications for the Chu Education Scholarship. There will be 2-4 scholarships given for Fall 2017.
The Chu Education Scholarship is intended to support Fellow's educational initiatives. Some examples of the scholarship would be MPH, MSPH, Quality Academy or Masters of Quality and Safety, Masters of Education, Masters of Business Administration, or other educational initiatives not covered above.

Applications should be emailed to rchandler@peds.uab.edu or delivered to Ronda Chandler in the Sergio Stagno Center, 4th Floor Dearth Tower, no later than April 10, 2017. The 2017 Chu Education Scholarship recipients will be announced in late May/early June 2017.

Questions? Please contact Ronda Chandler or Dr. Ann Klasner.
Deadline: April 10 | More Information
FROM THE PEDIATRIC RESIDENCY OFFICE 
GET TO KNOW YOUR RESIDENTS!

Check out FYI Fridays over the next few months for short bios on our residents. We hope the faculty and staff can learn more about our amazing residents! To begin, get to know next year's Chief Residents: 
SPENCER POORE

Medical School: 
Medical College of Georgia

Career Plans: Pulmonary Fellowship

Fun Fact: I would be mountain biking right now if I could.
BRYAUNA LEWIS

Medical School: University of Tennessee Health Sciences Center

Career Plans: Critical Care Fellowship

Fun Fact: Music makes me happy.

MICHELLE UDINE

Medical School: Rutgers New Jersey Medical School

Career Plans: Cardiology Fellowship

Fun Fact: I have a northern accent when I get mad.

FROM THE OFFICE OF FACULTY DEVELOPMENT (OFD) 
LEADERSHIP DEVELOPMENT SERIES - COACHING FOR RESULTS 

April 6 | 3 - 5 p.m. | Bradley Lecture Center

Coaching for Results
Matt Copeland
Training Instructor, OL&D

The UAB Pediatric Office of Faculty Development and UAB Organizational Learning and Development (OL&D) present the Leadership Development series quarterly. Join us on April 6!
More information. 
 
FROM THE PEDIATRIC RESEARCH OFFICE (PRO) 
FUNDING
 
UAB Nutrition Obesity Research Center (NORC) Pilot and Feasibility Program RFA
The NORC will fund at least three nutrition-related studies at up to $25,000/year for up to two years. Priority will be given to applications that demonstrate close relevance to the NORC mission, NORC core facility usage, and likelihood of future R01 funding. Letters of intent are due April 7 by 12 p.m., and more information is available here.
 
Joint Pilot Grant RFA from Comprehensive Cardiovascular Center and the Inflammation, Infection and Immunity (I3) Steering Committee
Funds can be used to generate key preliminary data and/or to continue advancing projects that are undergoing extramural peer review. Budgets must not exceed $50,000 for these one-year awards. Two page pre-proposals are due April 15 by 5 p.m. and should include title, names of PI and applicants, a brief statement of goals, how the proposed research addresses a critical population or clinical issues related to I3 and CVD, and plans for a subsequent application for extramural funding. For more information, please contact Megan Pickering.
 
SEMINARS AND TRAINING
 
Deadline to Submit Abstracts for Southeastern Pediatric Research Conference is April 3
Anyone may submit abstracts of up to 400 words (investigators, trainees, students and staff); topics related to child health research are encouraged. Up to 3 abstract authors from each non-local (>100 miles from Atlanta) institution will be selected to receive reimbursement for travel and hotel accommodations to provide an oral or poster presentation at the conference. To submit an abstract, click here.
 
Alabama Drug Discovery Alliance (ADDA) Lecture Series
This CCTS-sponsored drug discovery lecture series runs on Tuesdays from 12 - 1 p.m. in PCAMS (located at 1924 7th Ave So). The next lecture, How to Submit an IND, will be presented by Penny Jester and Maaike Everts on April 4. Information on other presentations and the GoToMeeting link are available here.
 
From Bench to Bedside, and Onward to Market: Commercializing Academic Software
The CCTS will host Wed., April 5, when Dr. Mark Yandell, Founder and Chief Scientific Officer of IDbyDNA, Inc. and University of Utah Professor of Human Genetics on April 5 from 4:45 - 6 p.m. at PCAMS (1924 7th Ave So). He will discuss how the nexus of three fields--metagenomic next-generation sequencing, precision medicine, and infectious disease--inspired him to build a business that empowers clinicians and researchers to identify any pathogen from any sample. For more information, or to connect remotely, click here.
PRE - AWARD RESEARCH

eRA Latest News

 
PUBLICATIONS
J Neurol Sci. 2017 Apr 15;375:371-375. doi: 10.1016/j.jns.2017.02.041. Evaluating the association of allergies with multiple sclerosis susceptibility risk and disease activity in a pediatric population. Bourne T, Waltz M, Casper TC, Kavak K, Aaen G, Belman A, Benson L, Candee M, Chitnis T, Graves J, Greenberg B, Gorman M, Harris Y, Krupp L, Lotze T, Mar S, Ness J, Olsen C, Roalstad S, Rodriguez M, Rose J, Rubin J, Schreiner T, Tillema JM, Kahn I, Waldman A, Barcellos L, Waubant E, Weinstock-Guttman B; US Network of Pediatric MS Centers.

Am J Clin Pathol. 2017 Mar 1. doi: 10.1093/ajcp/aqw191.009. Synthetic Human Neutrophil Peptide 1 Inhibits Platelet Adhesion and Aggregation on von Willebrand Factor/Collagen Surface Under Arterial Shear Stress Through Disulfide Bond Reduction Mechanism. McDaniel J, Zhen XL.

2017 Mar 1. doi: 10.1093/ajcp/aqw191.010. Human Neutrophil Peptides (HNPs) Inhibit Proteolytic Cleavage of von Willebrand Factor by ADAMTS13: A Potential Link between Inflammation and Thrombotic Thrombocytopenic Purpura. Pillai VG, Bao J, Zander CB, McDaniel J, Seeholzer SH, Bdeir K, Cines DB, Zhen XL.

J Clin Oncol. 2017 Mar 24:JCO2016717579. doi: 10.1200/JCO.2016.71.7579. Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1. Landier W, Hageman L, Chen Y, Kornegay N, Evans WE, Bostrom BC, Casillas J, Dickens DS, Angiolillo AL, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S.
Results of this research suggest that restrictions surrounding the administration of oral 6-mercaptopurine (6MP) chemotherapy (e.g., taking 6MP in the evening, without food or dairy products), may be unnecessary and may impair adherence to oral chemotherapy among children with acute lymphoblastic leukemia.


Mol Ther Oncolytics. 2017 Mar 1;5:1-10. doi: 10.1016/j.omto.2017.02.001. Pre-clinical Assessment of C134, a Chimeric Oncolytic Herpes Simplex Virus, in Mice and Non-human Primates. Cassady KA, Bauer DF, Roth J, Chambers MR, Shoeb T, Coleman J, Prichard M, Gillespie GY, Markert JM.

Pediatr Emerg Care. 2016 Jun;32(6):410-8. doi:10.1097/PEC.0000000000000827. Essentials of PEM Fellowship Part 2: The Profession in Entrustable Professional Activities. Hsu D, Nypaver M, Fein DM, McAneney C, Santen S, Nagler J, Zuckerbraun N, Roskind CG, Reynolds S, Zaveri P, Stankovic C, House JB, Langhan M, Titus MO, Dahl-Grove D, Klasner AE, Ramirez J, Chang T, Jacobs E, Chapman J, Lumba-Brown A, Thompson T, Mittiga M, Eldridge C, Heffner V, Herman BE, Kennedy C, Madhok M, Kou M.
This article describes the development of PEM entrustable professional activities (EPAs) and the relationship of these EPAs with existing taxonomies of assessment and learning within PEM fellowship. It summarizes the field in concepts that can be taught and assessed, packaging the PEM subspecialty into EPAs.
POSTERS AND PRESENTATIONS 

Rylie M. Hightower, BSN, RN, Graduate Research Assistant in Dr. Matthew Alexander's lab, had a poster presentation at the Muscular Dystrophy Association (MDA) Scientific Conference in Washington, DC on March 19-22, 2017. The title was, "Therapeutic administration of KPT-350 improves dystrophic muscle pathology."

The deadline for submission of information for inclusion in the FYI Fridays newsletter is 10 a.m. on the preceding Thursday.
 
Click here to submit information to FYI Fridays.
FYI FRIDAYS ARCHIVE
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