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Editor: Sara Davies 
OCTOBER 7, 2016
CHILDREN'S OF ALABAMA CELEBRATES OUR SUPERHEROES

October typically ushers in autumn outings and all things pumpkin, but at Children’s of Alabama, it’s all about superheroes. Children’s will again partner with Books-A-Million to kick off its Superhero Month festivities and its “The Power of Children’s” campaign, recognizing patients and staff as real-life superheroes while raising awareness of Children’s impact statewide.
 
The month-long celebration began Sept. 30 with a private superhero meet and greet at the hospital. Patients received capes and masks, and participated in arts and crafts activities. In addition, the Benjamin Russell Hospital for Children will be illuminated in blue every night in October in honor of patients and staff. A variety of superhero-themed events – from art activities to a special visit from not-so-average window washers – are scheduled throughout the month. To view the Children's press release, click here
SAVE THESE DATES!!!
CHILD HEALTH INVESTIGATIVE FORUM (CHIF) - OCTOBER 2016
Bradley Conference Center
Noon (lunch provided)

OCTOBER 7
Biopsychosocial Correlates of Pain in Youth with Eosinophilic Esophagitis: A Comparison to Other Pediatric Gastrointestinal Patients
Mary K. Lynch, M.A.
Graduate Student
Pediatric Gastroenterology, Hepatology and Nutrition
 
OCTOBER 21
TGF-Beta Pathobiology in CF Lung Disease
Tom Harris, M.D.
Assistant Professor
Pediatric Pulmonary
PEDIATRIC GASTROENTEROLOGY FACULTY CANDIDATE

Nicholas CaJacob, M.D.
Third Year Pediatric Gastroenterology, Hepatology, and Nutrition Fellow
University of Alabama at Birmingham

Dr. CaJacob will present “The Role Environmental Exposures in Eosinophilic Esophagitis” at Surgery Commons Auditorium 3rd floor on Oct. 10 at 4 p.m. Download the flyer
PEDIATRIC PULMONOLOGY FACULTY CANDIDATE

Ajay S. Kasi, MD, FAAP
Children’s Hospital of Los Angeles
Los Angeles, California
Pediatric Pulmonary Fellow                                                                           
Dr. Kasi will present “Congenital Central Hypoventilation Syndrome and Diaphragm Pacing” in the Benton Conference Room (Lowder Building 6th Floor) on Tuesday, Oct. 11 at 2:30 - 3:30 p.m. Download the flyer
VISITING FACULTY CO-HOSTED BY PEDIATRIC PULMONOLOGY & UAB CENTER FOR FREE RADICAL BIOLOGY

Claudia R. Morris, MD, FAAP
Associate Professor of Pediatrics and Emergency Medicine
Emory-Children’s Center for Cystic Fibrosis and Airway Disease Research
Emory University School of Medicine
Atlanta, Georgia
 
Dr. Morris will present “The Arginine Metabolome in Health and Disease” at the Biomedical Research Bldg II (901 19th Street South) in Conference Room 101 on Oct. 13 at 10:45 – 11:45 a.m. Download the flyer
AUTISM SUPPORT GROUP FOR SPANISH SPEAKING FAMILIES

On Oct. 15, 2016, the UAB Department of Pediatrics, Division of Developmental & Behavioral Medicine, Children’s Hospital of Alabama, Autism Society of Alabama and Help Me Grow are joining together to sponsor a Support Group meeting for Spanish speaking families with children with Autism. We welcome volunteers! If you are interested, contact Dr. Myriam Peralta or Justin Schwartz. Download the flyer.
THE CRON'S & COLITIS FOUNDATION OF AMERICA PRESENTS CASINO FOR A CAUSE

Save the date for Casino for a Cause on Thursday, Nov. 10 from 6 - 10 p.m. at Regions Field. The event will benefit Chron's & Colitis Foundation of America. More information and tickets available here
LAST CHANCE TO REGISTER FOR THE CANCER SYMPOSIUM!

Register for the 7th Annual Advancement in the care of Pediatric Cancer and Blood Disorders Symposium.
Thursday, Oct 20
8 a.m. – 4:30 p.m.
Here is the link for employees of both Children’s and UAB to register for FREE: Employee registration link
 
Both of the sites below house the public registration, which is only $35.  
https://www.childrensal.org/committedtoacure
https://www.childrensal.org/cancer
 
View the brochure which includes the agenda and learning objectives here.
FLU SHOTS AVAILABLE NEXT WEEK

WHERE: Employee Health Clinic - 3rd Floor McWane Building 
WHEN: Monday, Oct. 10 and Friday, Oct. 14

TIME: 7 a.m. - 4 p.m.

Click here for more information on flu shots for employees. 
PEDIATRIC RESIDENCY UPDATE
PEDIATRIC RESIDENCY REUNION WAS A HIT!

Additional thank you to everyone who helped put it on. We had over 200 attendees and 40 classes represented. Thank you to all who attended our FIRST Pediatric Residency Reunion! It was truly unforgettable!

Click here to view photos from the reunion. 
FROM THE PEDIATRIC OFFICE OF FACULTY DEVELOPMENT (OFD) 
SAVE THE DATE

OCTOBER 28

Managing Conflict
Duanna Pang-Dokland
Leadership Coach
Click here for flyer

AAMC MID-CAREER WOMEN FACULTY PROFESSIONAL DEVELOPMENT SEMINAR

The AAMC Mid-Career Women Faculty Professional Development Seminar is a three-and-a-half-day program designed for women holding medical school appointments at the associate professor level, and holding leadership positions within their discipline, department or institution. This year’s seminar will take place Dec.10-13 at the AT&T Executive Education Conference Center in Austin, TX.

The seminar covers leadership topics and skills specifically related to the mid-career faculty members such as conflict management, resilience and wellness, interpersonal communication, and finances, which are central to effective collaboration and leadership in various mission-critical activities.  

If you are interested in attending, please send your application directly to ofd@peds.uab.edu. The DOP deadline for applications is Oct. 10 at 5 p.m. Application and information can be found here

THE FUTURE OF WORKPLACE INCLUSION: LGBTQ EQUALITY

UAB Medicine and the UAB Office of Diversity, Equity, and Inclusion are sponsors of this free, half-day conference intended for corporate leaders, HR and diversity managers, state and municipal leaders and others interested in learning about the business and economic development case for equality. 
Date:  Oct. 14, 2016
Time:  8:30 a.m. – 3 p.m.
Location:  Harbert Center- 2019 4th 
Avenue South, Birmingham, AL 35203
Key Topics:  Updated discussion of the Corporate Equality Index (CEI), Best practices for inclusion policies, Panel Discussion, Time for Audience questions and breakout sessions.
Target Audience:  HR Staff, Diversity and Inclusion Staff, Recruiting Staff, Legal Staff, LGBT employees and LGBT leadership
Registration Link: hrc.im/BHMBusinessRSVP

DOWNLOAD THE UAB APP TODAY

The UAB App provides easy access to UAB Administrative Systems, UAB news and alerts, campus maps, and more. Click here to download the UAB App.

FROM THE PEDIATRIC RESEARCH OFFICE (PRO)
FUNDING
 
UAB Funding Opportunity – Researchers Omnibus Survey of Alabama
The Center for the Study of Community Health will fund up to four proposals for a total of $30,000. Awards provide UAB faculty investigators access to the UAB School of Public Health's Survey Research Unit to develop, collect, and compile preliminary survey data. Four-page proposals are due Oct. 31 on or before 5 p.m.

 
SEMINARS AND TRAINING
 
POSTPONED: The PRO Series – Tuesday, Oct. 18 at 1:00 p.m.
October’s speaker has been called out of town, so there will be no seminar on Oct. 18. 
 
Introduction to REDCap – Oct. 20 from 10 a.m. - 12 p.m.
REDCap (Research Electronic Data Capture) is 
a secure web-based application for building and managing online surveys and databases. This introductory class is targeted toward new or novice REDCap users in the DOP. Those interested will need to request a REDCap account prior to the class, if they do not already have one. Class size is limited; more information is available on the registration site
 
SAS Training
There has been a request for SAS Training. If you are interested, please email Cheryl Perry so we can determine whether there is enough interest for a group training. 
 
CCTS PSDS: How to Review a Paper in Under an Hour
Dr. Victor Darley-
Usmar, PhD, vice chair for research, UAB Department of Pathology, will present this seminar on Oct. 20 from 8:30 - 10 a.m. in PCAMS (located at 1924 7th Ave So). Topics include the peer review process, role of reviewers, journal goals, review format, and steps for expedient and fair reviewing. To register, click here.
GRANT AWARDS
 
Smita Bhatia (Ped - Hematology/Oncology) Reducing Risk of Anthracycline-Related Heart Failure after Childhood Cancer BECKMAN RESEARCH INSTITUTE (CITY OF HOPE). $35,543. 07/01/2016 - 06/30/2017.

Alexandra Martin (Ped - Endocrinology) Effect of GABA or Combination GABA/GAD on the Progression of Type 1 Diabetes Mellitus in Children Juvenile Diabetes Research Foundation International. $571,858. 09/01/2016 - 08/31/2019.​

Jayne Ness (Ped - Neurology) CHUGAI PHARMACEUTICAL COMPANY LTD. $371,479. 07/28/2016 - 11/30/2018.​
PUBLICATIONS

Medicine (Baltimore). 2016 Sep;95(39):e4909. In vivo expansion and activation of γδ T cells as immunotherapy for refractory neuroblastoma: A phase 1 study. Pressey JG, Adams J, Harkins L, Kelly D, You Z, Lamb LS Jr.

Ann Am Thorac Soc. 2016 Sep 29. Constrictive Bronchiolitis in Adolescents with Cystic Fibrosis with Refractory Pulmonary Decline. Harris WT, Boyd JT, McPhail GL, Brody AS, Szczesniak RD, Korbee LL, Baker ML, Clancy JP.
This manuscript evaluates lung histopathology in CF patients with rapid, refractory lung function decline. We report significant small airway remodeling in CF lung biopsy specimens, and emphasize the contribution of constrictive bronchiolitis (external impingement on small airway luminal patency) to pulmonary deterioration. We extend our previous reports of extensive myofibroblast activation and TGF-beta signaling in end stage to tissue to now highlight the role of these processes to mediate active disease progression.

Clin Cancer Res. 2016 Sep 28. pii
: clincanres.0610.2016. Somatic and germline TP53 alterations in second malignant neoplasms from pediatric cancer survivors. Sherborne A, Lavergne V, Yu K, Lee L, Davidson P, Mazor T, Smirnov IV, Horvai AE, Loh M, Dubois SG, Goldsby R, Neglia JP, Hammond S,Robison LL, Wustrack R, Costello JF, Nakamura A, Shannon KM, Bhatia S, Nakamura JL.
Data from this study support the concept that identifying germline TP53 variants at the time a primary cancer is diagnosed may identify patients at high risk for new subsequent cancer development, who could benefit from modified therapeutic strategies and/or intensive post-treatment monitoring.


J Clin Lipidol. 2016 Sep-Oct;10(5):1240-7. doi: 10.1016/j.jacl.2016.07.010. Body mass index and glycemic control influence lipoproteins in children with type 1 diabetes. Vaid S, Hanks L, Griffin R, Ashraf AP.
Glycemic control and weight management may have significant implications in T1DM. ApoB 100 concentrations in subjects with T1DM were determined by modifiable risk factors, BMI, HbA1C, and blood pressure, indicating the importance of adequate weight, glycemic, and blood pressure control for better diabetes care and likely lower CVD risk.


N Engl J Med. 2016; 375:1231-1241 September 29, 2016. DOI: 10.1056/NEJMoa1602044 Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. Alan T.N. Tita, M.D., Ph.D., Jeff M. Szychowski, Ph.D., Kim Boggess, M.D., George Saade, M.D., Sherri Longo, M.D., Erin Clark, M.D., Sean Esplin, M.D., Kirsten Cleary, M.D., Ron Wapner, M.D., Kellett Letson, M.D., Michelle Owens, M.D., Adi Abramovici, M.D., Namasivayam Ambalavanan, M.D., Gary Cutter, Ph.D., and William Andrews, M.D., Ph.D., for the C/SOAP Trial Consortium.

Am J Physiol Lung Cell Mol Physiol. 2016 Sep 30:
ajplung.00390.2016. doi: 10.1152/ajplung.00390.20i16. Of Mice and Men: Correlations Between microRNA-17~92 Cluster Expression and Promoter Methylation in Severe Bronchopulmonary Dysplasia. Robbins ME, Dakhlallah D, Marsh CB, Rogers LK, Tipple TE.

J Pediatr. 2016 Sep 27.
pii: S0022-3476(16)30877-0. doi: 10.1016/j.jpeds.2016.08.094. Variability in Management of First Cerebrospinal Fluid Shunt Infection: A Prospective Multi-Institutional Observational Cohort Study. Simon TD, Kronman MP, Whitlock KB, Gove N, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons JC 3rd, Whitehead WE, Mayer-Hamblett N; Hydrocephalus Clinical Research Network (HCRN).
This exhaustive prospective review of cerebrospinal fluid shunt infection management (both surgical and pharmacologic) revealed important areas of continuity and variation across the member institutions of the Hydrocephalus Clinical Research Network (HCRN).  These observations will form the basis of continued HCRN efforts to provide evidence-based, protocol driven care for children with hydrocephalus to help them live longer, more trouble-free lives.



JCI Insight. 2016 Sep 22;1(15):e87536. A ferret model of COPD-related chronic bronchitis. Raju SV, Kim H, Byzek SA, Tang LP, Trombley JE, Jackson P, Rasmussen L, Wells JM, Libby EF, Dohm E, Winter L, Samuel SL, Zinn KR, Blalock JE, Schoeb TR, Dransfield MT, Rowe SM.
This manuscript describes the first viable animal model of chronic bronchitis, recapitulating mucus hyper secretion, goblet cell hyperplasia, chronic cough, and airways obstruction.  Ferrets as a model of airway disease could open multiple new avenues of mechanistic and therapeutic research.


JCI Insight. 2016 Jul 7;1(10):e87919. Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children.
Ramos TN, Arynchyna AA, Blackburn TE, Barnum SR, Johnston JM.
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