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FYI Fridays
June 12, 2015
For the sixth consecutive year, Children’s of Alabama is ranked among the nation’s best children’s hospitals by U.S. News & World Report.  Seven of Children’s pediatric specialty services – Cardiology/Heart Surgery, Diabetes/Endocrinology, Nephrology, Neurology/ Neurosurgery, Neonatology, Urology and Pulmonology – were placed among the top 50 in the United States in the magazine’s 2014-15 Best Children’s Hospital rankings.  The complete listing and corresponding rankings may be found at 

The Best Children’s Hospitals rankings are based on a combination of clinical data and reputational surveys of pediatric specialists, 83 of the 184 hospitals surveyed ranked in at least one specialty.  The largest portion of each hospital’s score is based on a detailed questionnaire soliciting data on patient outcomes and clinically-related resources.  A small portion of the score (1/6) comes from an annual survey of pediatric specialists and subspecialists in each ranked specialty. Those receiving the survey were asked where they would send the sickest children in their specialty, setting aside considerations of location and expense.  Currently, U.S. News & World Report ranks 10 specialties including Cancer, Endocrinology, Gastroenterology, Heart/Heart Surgery, Kidney, Neonatology, Neurology/Neurosurgery, Orthopedics, Pulmonology and Urology.

We are very pleased that for the sixth straight year we are ranked among the nation’s best pediatric hospitals. Without question we provide exceptional care, service and comfort to the patients who are entrusted to us.  Click here to read the official news release, issued Tuesday, June 9, for more information.
Mike Warren

NIH released two notices outlining the agency's plans to enhance scientific rigor and experimental transparency in grant application and review. Specific details will be incorporated into revised grant application instructions that will be released later this year and will apply to all funding opportunity announcements for the January 25, 2016 application deadline and beyond. In summary, the new instructions will require applicants to include consideration of scientific premise, rigorous experimental design, and consideration of sex and other relevant biological variables in the Research Strategy portion of the application. Reviewers will be asked to evaluate scientific premise as part of Significance and rigorous experimental design and consideration of sex and other biological variables as part of the Approach. Thus, these three areas will be part of the reviewers' assessment of Overall Impact. Applicants will be required to address authentication of key resources in the Other Research Plan Sections, where reviewers will be asked to comment on the plan but not consider it when scoring overall impact.

Specific details regarding NIH's expectations for addressing Scientific Premise, Rigorous Experimental Design, Consideration of Sex and Other Relevant Biological Variables, and Authentication of Key Biological and/or Chemical Resources can be found here. A companion notice provides additional details regarding expectations for Consideration of Sex as a Biological Variable and can be found here, and additional background can be found on the Rock Talk blog.

Resident Senior Talks
have been announced, click here for the current schedule.
Pre-Award Research
Office News

NIH eSubmission Items of Interest - June 10, 2015

Pediatric Academic Society
Call for Session and Speaker Proposals
Proposal Submission Deadline:
June 26, 2015; 5:00PM CST

Registration for July 1-2 Precision Medicine Initiative (PMI) Participant and Community Engagement Workshop is Now Open. NIH- PMI is  seeking public input on effective community engagement strategies to advance the ability of the Initiative to conduct transformative research to address health disparities. 
Learn more.

Damon Runyon-Rachleff Innovation Award Application
Deadline: July 1, 2015 

The Center for Clinical and Translational Science (CCTS) Partner Network invites letters of intent for KL2 Mentored Career Development Awards in Translational Research. Letter of intent deadline: July 13. Click here for more information. 
Wednesday June 17th
Surgery Commons Library
Promotion: What You Need to Know

Lunch provided if you RSVP to
by Monday June 15th
Hope to see everyone there!!
Grant News
Michael Stalvey, MD
(Ped-Endocrinology) was awarded a pilot project on the new Cystic Fibrosis Research Center P30 grant.  Total funding is $75,000 per year for two years.
In last week's newsletter, it was incorrectly reported that Dr. Ashley Brown would be doing an Emergency Medicine Fellowship. Dr. Brown will be doing her Pediatric Critical Care Fellowship at UAB.

5th Annual Research and Innovations in Medical Education (RIME) Week
September 16-18, 2015

Click here to find a list of events coming soon to the Department
 Pediatric Grand Rounds Link
The deadline for submission of
information for inclusion in the
FYI Fridays newsletter is
10:00am on the preceding Thursday.
FYI Fridays Archive
Congratulations to the following Residency Program Awardees:

Quarterback Club Subspecialty Education: Dr. Brett Turner
The Graduating Class of 2002 established this award to recognize the contributions of a selected Fellow to resident education.  The recipient of this award is selected by the graduating senior residents. 

Sergio Stagno Friend of the Housestaff: Dr. Candice Dye
In 1996, The Residency Program initiated an award entitled the Sergio Stagno, M.D. Friend of the Housestaff Award. This award was created to recognize an individual who demonstrates a strong commitment to the education of residents and is an extraordinary advocate for residents and interns. 

Ralph Tiller Distinguished Faculty: Dr. Nancy Tofil
This award recognizes the faculty member the senior resident class believes has contributed most to their overall education and training experience.

Michele St Romain Housestaff Award: Dr. Shelly Mercer
This is the highest honor in our residency program. The award was established by the graduating class of 1993 in honor of their classmate, Michele St. Romain, who mysteriously disappeared in 1991. The award recognizes a PGY-3 or PGY-4 resident who demonstrates those characteristics most admired in Michele – enthusiasm, compassion and dedication to improving the health of children.

Joe LaRussa Interns of the Year Award:
 Megan Willis, M.D. and Charles Schlappi, M.D

This award was established by the family of Dr. Joe B. LaRussa, who was an intern of the year in his UAB Pediatric Residency class. Selected interns are role models who demonstrate compassion, dedication and leadership.  Their selection is based on input from all residents and faculty.
APS Announces New PAS Program Committee Representatives
Drs. Susan H. Guttentag (Monroe Carell Jr. Children's Hospital at Vanderbilt), Daniel C. West (University of California, San Francisco), and Waldemar A. Carlo (University of Alabama at Birmingham) will serve as American Pediatric Society (APS) representatives to the Pediatric Academic Societies (PAS) Program Committee. Dr. Guttentag has served as an APS Representative for the past three years and has agreed to serve one additional year to enable term staggering; Drs. West and Carlo will serve three-year terms. All three APS Representatives will help to select and organize a strong and well balanced scientific program for the 2016 PAS Annual Meeting.
Recent and Upcoming Publications
J Clin Transl Endocrinol. 2015 Jun 1;2(2):77-82. Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals. Hanks LJ, Gutiérrez OM, Bamman MM, Ashraf A, McCormick KL, Casazza K.
The objectives of this cross-sectional study were to assess FGF21 levels across age groups (childhood to elder adulthood) in healthy individuals, and investigate whether body composition indices are associated with age-related differences in circulating FGF21.  The findings suggest in a healthy population circulating FGF21 displays an age-related increase independent of body composition differences, and at lower FGF21 level, bone density may explain the association between FGF21 and age.  A potential age effect in response to metabolic demand is highlighted over the lifecourse.   

Clin Perinatol. 2015 Jun;42(2):321-336. doi: 10.1016/j.clp.2015.02.005. Epub 2015 Apr 15. Newborn Craniofacial Malformations: Orofacial Clefting and Craniosynostosis. Hamm JA, Robin NH.
Craniofacial malformations, including orofacial clefting and craniosynostosis, are among the most common serious birth defects.  In this article, the authors review the epidemiology, pathogenesis, diagnosis and treatment of non-syndromic and selected syndromic instances of these craniofacial malformations. 
 2014 Oct;8:54-61. doi: 10.1016/j.coviro.2014.06.003. Epub 2014 Jul 16. Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance. James SH, Prichard MN.


Ambika Ashraf, Lynae Hanks, James Heath Pelham, Shalini Vaid. (June 11-14, 2015) Higher prevalence of atherogenic lipoproteins in overweight/obese T2DM adolescents relative to T1DM counterparts. Poster presentation at National lipid association meeting, Chicago, IL.

James Heath Pelham, Lynae Hanks, Ambika Ashraf. (June 11-14, 2015) Analysis of Dyslipidemia in Children with Type 2 Diabetes Mellitus. Poster presentation at National lipid association meeting, Chicago.

Lynch MK, Goodin BR, Dimmitt R, Avis KT. (2015, June). Objective And Subjective Report Of Sleep Problems In Children With Eosinophilic Esophagitis. Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014 Seattle, WA.

Lynch MK, Avis KT. (2015, June). The Relationship Between Positive Airway Pressure (PAP) Adherence And Quality Of Life In Children With Obstructive Sleep Apnea Syndrome (OSAS)". Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014 Seattle, WA.

Hartzell K, Avis KT, Feig D, Lozano DJ. (2015, June). Frequency of Sleep Disorders in a Hypertensive Pediatric Population. Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014 Seattle, WA.

Avis, KT., Gamble, KL, Schwebel, DC. (2015, June). Effect of Positive Airway Pressure therapy in children with OSAS: Does PAP use reduce pedestrian injury risk? Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014, Seattle, WA.

Avis KT, Shen J, Schwebel DC. (2015, June). Sleep Habits, Patterns and Disturbances in Children with Hypersomnia. Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014, Seattle, WA.

Rouse J, Smith R, Schwebel, DC, Avis, KT. (2015, June). How do “all-nighters” influence safety and cognition among college students? Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014, Seattle, WA.

Smith R, Rouse J, Johnston A, Schwebel DC, Avis KT. (2015, June). Effects of total sleep deprivation on simple reaction time, vigilance, and visual attention in college students. Poster accepted for presentation at the annual meeting of the Associated Professional Sleep Societies, SLEEP 2014, Seattle, WA.


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